Celox™ is made using chitosan. Chitosan, when treated in the correct way, has many special properties that make it the ideal choice for use in hemostatic agents, including:
- Rapidly clots blood
- It is hypoallergenic
- Has natural antibacterial properties
- Biodegradable and non-toxic
What is Chitosan?
Chitosan is a natural polymer extracted from crustacean shells such as shrimp and crabs. Chitosan is a polysaccharide (long chain of sugars) and has a known metabolic pathway. That means any chitosan left in the body is broken down by the bodies normal enzymes and converted into materials routinely present in the human body.
Chitosan is digested by lysozyme, a human enzyme present is tears, saliva and mucus. It breaks down into glucosamine (a sugar already present in the body that helps lubricate joints). Reference (Int. J. Biol. Macromol., 1992, Vol 14 August).
Chitosan is used widely and is in products such as medical bandages, diet aids and some cosmetics. It is an approved food ingredient.
How We Use Chitosan
We use a very special grade of chitosan to make Celox™ hemostats. It is a highly purified derivative of shrimp shells caught in the pure waters of the arctic ocean. The rigorous safety testing for this material includes allergy tests on human subjects who tested positive for fish/shrimp allergy. None of the subjects showed any reaction to the type of chitosan that we use.
The chitosan in Celox™ has been reacted to optimise its effectiveness in our hemostatic agents. This improves the solubility and bioabsorbability improving the speed with which our products can stop bleeding.