How Celox Works
Celox™ granules are actually very high surface area flakes. When they come in contact with blood, Celox™ swells, gels, and sticks together to make a gel like clot, without generating any heat. Celox™ does not set off the normal clotting cascade, it only clots the blood it comes directly into contact with.
This mode of action has a number of major benefits:
- Works in hypothermic conditions*.
- Clots heparinized blood*.
- No heat generated*.
- Leftover material is naturally absorbed by the body.
Celox works on hypothermic (cold) blood*
Severe traumatic blood loss quickly leads to the victim becoming hypothermic, irrespective of the outside temperature. Hypothermic blood is coagulopathic (does not clot normally) and so becomes harder to stop. Celox effectiveness in hypothermic conditions has been tested independently3.
Blood thinners (anticoagulants)
Celox works on casualties using blood thinners (anticoagulants) and anti-platelet therapy such as aspirin. An increasing number of people are on anticoagulants, presenting an extra challenge if they are injured. Celox has been tested and shown to clot heparinized blood*. Further laboratory tests on blood containing heparin or warfarin have been published 1,2,3.
Published results use Celox in patients with severe coagulation problems4. These are cases of bleeding after complex surgery where other hemostatic agents had failed to control the problem.
“Celox simply clots the blood once it comes directly into contact with it, thus not setting off the normal clotting cascade. Since chitosan works independently from the physiological clotting mechanisms, it has also been proved to work in the presence of common anti-coagulants such as warfarin as well as in the presence of heparin”
Celox does not produce any heat at all when it is used*, unlike some mineral-based hemostats.
Celox™ is made with chitosan, a natural polysaccharide. Chitosan has a known metabolic pathway. That means any left in the body is broken down by the body’s normal enzymes and converted into materials normally present in the body. This is unlike other hemostats that can leave mineral residuals in the body6,7. Chitosan is digested by lysozyme, a human enzyme which is present is tears, saliva and mucus. It breaks down to give glucosamine a sugar already present in the body and helps lubricate joints8.
The chitosan in Celox is a specific high quality grade selected for medical use from a shellfish source and the product has been through extensive safety testing to FDA requirements and the most stringent class of European Medical Device regulations. As part of this work the chitosan has been tested on human subjects with confirmed fish or shrimp hypersensitivity and none of the subjects showed any skin reaction to the chitosan5.