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About Celox

Celox stands for treating the most severe trauma injuries by providing innovative, reliable lifesaving medical products.  Our product range includes hemostatic dressings and chest seal dressings.


Hemostatic Dressings

Hemostatic agents are dressings designed to stop external bleeding from traumatic injuries such as gunshot, blast or stab wounds, but also injuries from vehicle accidents or power tools. They are used at the very first point of care and whenever needed before a patient reaches surgery.

Chest Seals

Penetrating injuries to the chest can lead to one or both lungs collapsing and cause death by loss of oxygen.  This is the third most common cause of preventable battlefield death23.  Chest seal dressings work by sealing over the injury to manage the situation and allow the responder to then treat pneumothorax (fluid in chest cavity) or hemothorax (blood in chest cavity).  Our chest seal dressing, FOXSEAL, provides a dependable treatment for open chest wounds in the most challenging situations.


Applications for Celox include:

  • Military*  – Celox Gauze is approved by the US Department of Defense Committee on Tactical Combat Casualty Care – CoTCCC
  • Emergency Medical Services
  • Public Safety
  • Police
  • Fire
  • Personal


Why Celox is superior

Celox Rapid Gauze stands out due to its speed and effectiveness.  It drastically reduces the treatment time needed to hold pressure to control bleeding, from three minutes to just one minute for a severe arterial injury.  It speeds up the time applying the dressing to the wound, saving precious seconds, which quickly add up in a traumatic situation.  

The Evidence

Celox has excellent clinical results.  Some of the clinical reports and key independent pre-clinical studies on Celox are summarised below. Please contact us for a monograph of all relevant studies.

1.  Human clinical results with Celox.

1.1  Field Experience with a Chitosan-based Hemostatic Dressing2

Celox Gauze was used to control bleeding in a range of severe injuries by military forces (in Afghanistan) and Emergency Services use in the Netherlands. 

Conclusion: “a safe and useful tool in stopping or controlling external blood loss”

  • Includes gunshot injury, road traffic collision, crush and fall injuries
  • In all the cases there was no leakage or re-bleeding when it was removed, up to 24 hours later


1.2  Celox (Chitosan) for Hemostasis in Massive Traumatic Bleeding: Experience in Afghanistan 3

A report from use in Afghanistan studies 21 cases where Celox has been used to treat gunshot wounds including neck, shoulder, upper and lower limb injuries (see figure).  Bleeding was life-threatening in 15 cases.  

“A quick and efficient hemostatic action, producing a stable clot”

  • Stopped bleeding in all cases
  • Included cases where tourniquet use was not effective




1.3   “A Pre-hospital Technique for Controlling Hemorrhage from Traumatic Perineal and High Amputation Injuries 29 

This report describes the technique used “to good effect on recent deployments” during operations in Afghanistan, to treat high lower extremity amputation and pelvic injuries.


2.  Key Pre-clinical Studies

2.1  Chitosan Based Advanced Hemostatic Dressing is Associated with Decreased Blood Loss in Swine Uncontrolled Hemorrhage Model 9

This study was carried out on a model of Care Under Fire, comparing Celox Rapid, Combat Gauze* and plain gauze.  

  • Hemostasis achieved:  Celox Rapid 100 %, Combat Gauze 83 %, plain gauze 83 %
  • Blood lost during treatment was significantly reduced for Celox Rapid by 60 % compared to Combat Gauze and by 71% compared to plain gauze
  • Time taken to pack the wounds was significantly reduced for Celox Rapid compared to Combat Gauze or plain gauze


2.2  Comparison of Novel Hemostatic Dressings with QuikClot Combat gauze in a standardized swine model of  Uncontrolled Hemorrhage 5

This study was carried out in order to review the DoD recommendation for choice of hemostatic gauze. 


  • 90% survival for Celox Gauze, other products achieved 50 – 70 %
  • Significantly reduced blood loss 10 minutes after treatment for Celox Gauze, compared to Combat Gauze
  • Celox Gauze final blood loss 29 ml/kg, compared to 63 for Combat Gauze and 32-64 for other treatments

Note: one of the products in the study, Celox Trauma Gauze has been discontinued since 2012.  We market only Celox Gauze and the new Celox Rapid Gauze for hemostatic gauze due to their superior performance.


2.3  Advanced Hemostatic Dressings Are Not Superior to Gauze for Care Under Fire Scenarios 24

This was a model with reduced compression time, to reflect the limits of “care under fire”.

  • Celox Gauze achieved 75 % observed hemostasis, compared to 50 % for Combat Gauze
  • Post-treatment blood loss  for Celox Gauze was 110 ml, compared to 194 ml for Combat Gauze

Used By Professionals Everywhere

MilitaryCelox forMilitaryLaw EnforcementCelox forLaw EnforcementHospitalsCelox forHospitalsEmergency Medical ServicesCelox forEmergency Medical ServicesRemote MedicineCelox forRemote MedicinePublic AccessCelox forPublic Access

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Medtrade Products Ltd
Electra House, Crewe Business Park, Crewe, UK, CW1 6GL


© Medtrade Products Ltd 2024

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